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Solutions

Respiratory

Banook brings together world-class respiratory science, cutting-edge digital biomarkers, and a global network of pulmonary experts to optimize therapeutic development across the full spectrum of respiratory diseases. Leveraging Functional Respiratory Imaging (FRI) alongside comprehensive pulmonary function testing, we deliver sensitive, patient-centric endpoints that enhance trial precision and accelerate decision-making.

smiling man in doctor's office for heart check-up

Solutions

Respiratory

Banook brings together world-class respiratory science, cutting-edge digital biomarkers, and a global network of pulmonary experts to optimize therapeutic development across the full spectrum of respiratory diseases. Leveraging Functional Respiratory Imaging (FRI) alongside comprehensive pulmonary function testing, we deliver sensitive, patient-centric endpoints that enhance trial precision and accelerate decision-making.

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Experience

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Transforming Respiratory Trial Endpoints with Precision and Insight

Respiratory diseases present unique challenges: heterogeneity of pathophysiology, variable patient response, and traditional endpoints that may lack regional or mechanistic specificity. Banook provides advanced solutions that deliver deeper insights into lung structure and function through:

Functional Respiratory Imaging (FRI): A proprietary, non-invasive technique combining low-dose high-resolution CT and computational fluid dynamics to generate 3D, patient-specific biomarkers of airway geometry, airflow, ventilation distribution, aerosol deposition, and more — enabling precise assessment of disease mechanisms and therapeutic effects at regional and whole-lung levels. 

Functional Respiratory Imaging (FRI): A proprietary, non-invasive technique combining low-dose high-resolution CT and computational fluid dynamics to generate 3D, patient-specific biomarkers of airway geometry, airflow, ventilation distribution, aerosol deposition, and more — enabling precise assessment of disease mechanisms and therapeutic effects at regional and whole-lung levels. 

Functional Respiratory Imaging (FRI): A proprietary, non-invasive technique combining low-dose high-resolution CT and computational fluid dynamics to generate 3D, patient-specific biomarkers of airway geometry, airflow, ventilation distribution, aerosol deposition, and more — enabling precise assessment of disease mechanisms and therapeutic effects at regional and whole-lung levels. 

Pulmonary Function Testing (PFT): Standardized, high-quality assessment modalities including spirometry, Fractional exhaled Nitric Oxide (FeNO), oscillometry, and Diffusion Capacity for Carbon Monoxide (DLCO), collectively capturing airflow limitation, airway inflammation, mechanical properties, and gas-exchange capacity with robust operational performance across sites.

Pulmonary Function Testing (PFT): Standardized, high-quality assessment modalities including spirometry, Fractional exhaled Nitric Oxide (FeNO), oscillometry, and Diffusion Capacity for Carbon Monoxide (DLCO), collectively capturing airflow limitation, airway inflammation, mechanical properties, and gas-exchange capacity with robust operational performance across sites.

Pulmonary Function Testing (PFT): Standardized, high-quality assessment modalities including spirometry, Fractional exhaled Nitric Oxide (FeNO), oscillometry, and Diffusion Capacity for Carbon Monoxide (DLCO), collectively capturing airflow limitation, airway inflammation, mechanical properties, and gas-exchange capacity with robust operational performance across sites.

Together, these modalities form a comprehensive respiratory endpoint toolkit—enhancing sensitivity to treatment effects and supporting strong regulatory strategies.

Fluidda website

Medical experts

A Global Network of Pulmonary Leaders

Banook is backed by an international panel of pulmonary experts and key opinion leaders who support trial teams across scientific, operational, and regulatory domains:

Respiratory Methodology & Endpoint Design: Collaborative protocol development integrating imaging and functional readouts tailored to mechanism, indication, and phase.

Respiratory Methodology & Endpoint Design: Collaborative protocol development integrating imaging and functional readouts tailored to mechanism, indication, and phase.

Respiratory Methodology & Endpoint Design: Collaborative protocol development integrating imaging and functional readouts tailored to mechanism, indication, and phase.

Expert Interpretation & Advisory: Accessible pulmonary clinicians and imaging scientists provide consultative support on biomarker selection, interpretation, and clinical relevance.

Expert Interpretation & Advisory: Accessible pulmonary clinicians and imaging scientists provide consultative support on biomarker selection, interpretation, and clinical relevance.

Expert Interpretation & Advisory: Accessible pulmonary clinicians and imaging scientists provide consultative support on biomarker selection, interpretation, and clinical relevance.

Regulatory Alignment: Guidance on endpoint justification and alignment with regulatory expectations for respiratory drug and device development.

Regulatory Alignment: Guidance on endpoint justification and alignment with regulatory expectations for respiratory drug and device development.

Regulatory Alignment: Guidance on endpoint justification and alignment with regulatory expectations for respiratory drug and device development.

Our experts partner with sponsors from first-in-human through Phase III and post-market studies, ensuring methodological rigor and continuity of insight throughout the clinical program.

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Challenges

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Reducing Variability and Increasing Precision

Respiratory trials often face hurdles such as high variability, limited sensitive endpoints, and difficulty demonstrating regional effects in heterogeneous disease populations. Banook Respiratory addresses these through:

Increased Endpoint Sensitivity: FRI biomarkers capture structure–function relationships and therapeutic impact beyond global lung metrics, enabling earlier and clearer differentiation between arms.

Increased Endpoint Sensitivity: FRI biomarkers capture structure–function relationships and therapeutic impact beyond global lung metrics, enabling earlier and clearer differentiation between arms.

Increased Endpoint Sensitivity: FRI biomarkers capture structure–function relationships and therapeutic impact beyond global lung metrics, enabling earlier and clearer differentiation between arms.

Deep Physiologic Insight: Quantitative regional measures of airway resistance, ventilation distribution, and aerosol deposition provide mechanistic insights that inform dose selection and responder profiling.

Deep Physiologic Insight: Quantitative regional measures of airway resistance, ventilation distribution, and aerosol deposition provide mechanistic insights that inform dose selection and responder profiling.

Deep Physiologic Insight: Quantitative regional measures of airway resistance, ventilation distribution, and aerosol deposition provide mechanistic insights that inform dose selection and responder profiling.

Comprehensive Functional Readouts: Combining imaging with PFTs such as FeNO for airway inflammation, oscillometry for small-airway mechanics, and DLCO for gas-exchange efficiency allows multidimensional characterization of respiratory response.

Comprehensive Functional Readouts: Combining imaging with PFTs such as FeNO for airway inflammation, oscillometry for small-airway mechanics, and DLCO for gas-exchange efficiency allows multidimensional characterization of respiratory response.

Comprehensive Functional Readouts: Combining imaging with PFTs such as FeNO for airway inflammation, oscillometry for small-airway mechanics, and DLCO for gas-exchange efficiency allows multidimensional characterization of respiratory response.

Standardized, High-Quality Data Across Sites: Robust operational frameworks ensure PFT quality control, imaging protocol harmonization, and consistent endpoint performance in multinational studies.

Standardized, High-Quality Data Across Sites: Robust operational frameworks ensure PFT quality control, imaging protocol harmonization, and consistent endpoint performance in multinational studies.

Standardized, High-Quality Data Across Sites: Robust operational frameworks ensure PFT quality control, imaging protocol harmonization, and consistent endpoint performance in multinational studies.

Solutions Tailored to Your Study Needs

Building Stronger Respiratory Trials

Banook supports a wide range of respiratory indications — including asthma, COPD, cystic fibrosis, interstitial lung disease, and other obstructive or restrictive conditions — across all phases of clinical development. Our solutions include:

FRI Biomarker Generation & Analysis

FRI Biomarker Generation & Analysis

FRI Biomarker Generation & Analysis

Centralized Pulmonary Function Testing Services

Centralized Pulmonary Function Testing Services

Centralized Pulmonary Function Testing Services

Imaging Protocol Development & Quality Assurance

Imaging Protocol Development & Quality Assurance

Imaging Protocol Development & Quality Assurance

Endpoint Interpretation & Reporting

Endpoint Interpretation & Reporting

Endpoint Interpretation & Reporting

Integrated Respiratory Data Streams for Regulatory Submissions

Integrated Respiratory Data Streams for Regulatory Submissions

Integrated Respiratory Data Streams for Regulatory Submissions

Together, these services enable sponsors to build more informative respiratory trials with endpoints that matter to patients, clinicians, and regulators alike.

stethoscope on a computer keyboard

Devices

Why Banook for Respiratory

Your Partner in Respiratory Clinical Development

With the integration of Fluidda’s 20+ years of leadership in Functional Respiratory Imaging, Banook is uniquely positioned to deliver an unmatched respiratory clinical trial capability — coupling innovative imaging science, comprehensive functional testing, and deep pulmonary clinical expertise. 

Whether your program targets novel biologics, small molecules, inhaled therapies, or medical devices, Banook Respiratory offers a scientifically rigorous and operationally scalable solution designed to enhance decision-making and support successful outcomes.

stethoscope on a computer keyboard
stethoscope on a computer keyboard
stethoscope on a computer keyboard
Request a quote

Interested in how Banook Respiratory can elevate your clinical trial’s respiratory endpoints?

Contact us

Request a quote

Interested in how Banook Respiratory can elevate your clinical trial’s respiratory endpoints?

Contact us

Request a quote

Interested in how Banook Respiratory can elevate your clinical trial’s respiratory endpoints?

Contact us